Author: Sordet-Guépet H, Manckoundia P.
Source: British Journal of Medicine and Medical Research.
Year: 2014
Comment:
The researchers, whose work also examines mercury, lead (Pb) and other heavy metals, conclude, "The lack of overall agreement about precautions for heavy metals does not mean that latent and prolonged exposure to these products is safe, especially with regard to the potential risk of worsening neurodegenerative diseases."
Abstract / Excerpt:
Methodology: A literature search was conducted on PubMed using the keywords dementia, dementia syndrome, Alzheimer disease, Alzheimer type dementia, exposure, neurotoxicity aluminium, mercury, pesticide. After reading all of the abstracts and ruling out irrelevant articles, only relevant articles in English or French were selected. We read more than 600 abstracts and based on these we selected and read 352 articles, 176 for each of the two authors. Finally, our bibliography includes 78 articles.
Results: The neurotoxicity data from animal experiments are old, and in the professional environment there is no evidence regarding the gradient of environmental toxicity. Synergistic, multiple-factor neurotoxicity is complex and difficult to document epidemiologically as it is due to a cumulative toxic continuum rather than a dose/effect relationship. Within this recognized multi-causal model of neurodegenerative diseases, particularly Alzheimer disease, chronic exposure to neurotoxic products has a real pathogenic effect on the central nervous system though certain aspects of this effect are not entirely proven.”
Citation:
Sordet-Guépet H, Manckoundia P. Alzheimer Disease and Environmental Exposure to Neurotoxic Factors: A Controversy. British Journal of Medicine and Medical Research. 2014; 4(34): 5298.