Diagnosis of heavy metal loading by the oral DMPS and chewing-gum tests.

Author: Gerhard I, Waldbrenner P, Thruo H, Runnebaum B.

Source: Klin Lab.

Year: 1992

Comment:

Abstract / Excerpt:

Heavy metals are ingested in the diet or by inhalation. With ingestion of large amounts of heavy metals, or in disorders of excretion through liver, kidneys and intestines, they are stored in various repositories (e.g., central nervous system, bones, kidneys, liver, pancreas). They pass through the placenta and are likewise stored in fetal organs, where they are discernible partially in still higher concentrations than in the maternal organism. Dependent on time, amount and type of heavy metals, various symptoms and global effects can appear, which range from so-called psychosomatic disorders all the way up to severe poisonings with organic involvement. Because of the storability of heavy metals, the ability to demonstrate concentrations in the blood or urine is limited to acute poisonings. Yet chelators can effect release of heavy metal s from the repositories, which has been known already for decades in treatment of poisonings. And so the next step was to introduce, for a stimulation test, a chelator which has minimal unwanted side effects and yet is well suited to induce a safe heavy-metal excretion.

Citation: Gerhard I, Waldbrenner P, Thruo H, Runnebaum B. Diagnosis of heavy metal loading by the oral DMPS and chewing-gum tests. Klin Lab. 1992; 38:404-11. [Translated into English.]