Increased Systemic Malondialdehyde Levels and Decreased Mo/Co, Mo/Hg2+, Co/Fe2+ Ratios in Patients with Long-Term Dental Titanium Implants and Amalgams.

Author: Cabaña-Muñoz ME, Parmigiani-Izquierdo JM, Camacho Alonso F, Merino JJ.

Source: Journal of Clinical Medicine

Year: 2019

Comment:

Abstract / Excerpt:

INTRODUCTION:
the biological safety of dental biomaterials has been questioned in human studies.

MATERIAL AND METHODS:
Several heavy metals/oligoelements were compared by Inductive Coupled Mass Spectrometry (ICP-MS) in hair samples from 130 patients (n = 54 patients with long-term titanium dental implants and amalgams (A + I group), 51 patients with long-term dental amalgam alone (A group), as well as controls (n = 25: without dental materials) of similar age. All patients (except controls) had had titanium dental implants and/or dental amalgams for at least 10 years (average: 17). We evaluated whether A + I patients could present higher systemic malondialdehyde levels (MDA) as compared to the A group.

RESULTS:
The A + I group have lower molybdenum levels (A + I) and reduced Mo/Co and Mo/Fe2+ ratios, which could predispose them to oxidative stress by raising MDA levels as compared to the A group alone; our findings suggest that higher Co levels could enhance oxidative stress in the A + I group. However, there were no differences on metals from titanium alloy (Ti-6Al), Cr from crowns or Hg2+, Sn, Zn2+, Cu2+ levels between the A + I and A groups.

CONCLUSION:
patients with long-term dental titanium and amalgams have systemic oxidative stress due to rising MDA levels and lower Mo/Co and Mo/Fe2+ ratios than those with amalgams alone.

Citation: Cabaña-Muñoz ME, Parmigiani-Izquierdo JM, Camacho Alonso F, Merino JJ. Increased Systemic Malondialdehyde Levels and Decreased Mo/Co, Mo/Hg2+, Co/Fe2+ Ratios in Patients with Long-Term Dental Titanium Implants and Amalgams. Journal of Clinical Medicine. 2019 (1):86.