In vitro study of thimerosal reactions in human whole blood and plasma surrogate samples.

Author: Trümpler S, Meermann B, Nowak S, Buscher W, Karst U, Sperling M.

Source: J Trace Elem Med Biol.

Year: 2014

Comment:

Abstract / Excerpt:

“In this work, human whole blood and physiological simulation solutions were incubated with thimerosal to investigate its behaviour and binding partners in the blood stream. Inductively coupled plasma with optical emission spectrometry (ICP-OES) was used for total mercury determination in different blood fractions, while liquid chromatography (LC) coupled to electrospray ionisation time-of-flight (ESI-TOF) and inductively coupled plasma-mass spectrometry (ICP-MS) provided information on the individual mercury species in plasma surrogate samples. Analogous behaviour of methylmercury and ethylmercury species in human blood was shown and an ethylmercury-glutathione adduct was identified.”

Citation:

Trümpler S, Meermann B, Nowak S, Buscher W, Karst U, Sperling M. In vitro study of thimerosal reactions in human whole blood and plasma surrogate samples. J Trace Elem Med Biol. 2014; 28(2): 125-30.