Alzheimer's disease in the National Academy of Sciences-National Research Council Registry of Aging Twin Veterans. III. Detection of cases, longitudinal results, and observations on twin concordance.

Author: Breitner JC, Welsh KA, Gau BA, McDonald WM, Steffens DC, Saunders AM, Magruder KM, Helms MJ, Plassman BL, Folstein MF, et al.

Source: Arch Neurol.

Year: 1995

Comment:

While dental mercury is not the subject of this study, the research explores genetic factors in Alzheimer's disease and suggests studies for environmental factors.

Abstract / Excerpt:

“The multistage case-detection approach achieved reliable and valid diagnoses of AD with high apparent sensitivity but substantial attrition after initial screening. Genetic influences in AD at this age are limited, except among homozygotes for allele epsilon 4 at APOE. Subjects with early-onset AD who lack the epsilon 4 allele are not rare, and their condition appears to have little genetic influence. They should be ideal for studies on environmental cause of AD.”

Citation:

Breitner J, Kathleen A. Welsh KA, Gau BA, McDonald WM, Steffens DC, Saunders AM, Kathryn M. Magruder KM et al. Alzheimer's Disease in the National Academy of Sciences--National Research Council Registry of Aging Twin Veterans: III. Detection of Cases, Longitudinal Results, and Observations on Twin Concordance. Archives of Neurology. 1995; 52(8):763.