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“…it may be dangerous to inject a serum containing merthiololate into a patient sensitive to merthiolate.”

“The symptoms of chronic mercury poisoning are erethism, tremor and stomatitis. Seventy-two men in a thermometer workshop and 11 in a chemical works making pharmaceutical compounds of mercury were examined. Mass observation suggests that the thermometer workers suffered from mild chronic mercury poisoning, whereas little abnormality was seen in the older group of chemical workers. Atmosphere and urine estimations showed that the thermometer makers were excreting up to 10 times as much mercury in a day as could possibly be absorbed from the atmosphere.”

“Merthiolate should never be given in amounts exceeding 0.15 gram per 100 lbs. of body weight; nor more frequently than once in 10 days.  This drug should not be used if there is evidence of active hemorrhagic nephritis.”

“The effect of an antiseptic on body tissue is relatively of greater importance than the ability of that antiseptic to destroy living microorganisms.”

“The toxic effect of germicides when tested on human or guinea pig blood as a tissue appears to be directed against the humoral in contrast to the cellular elements.”

“Reported instances of dermatitis or stomatitis from the mercury of amalgam fillings are rare, but undoubtedly such cases occur more frequently than a review of the literature would indicate. We have recently observed 2 examples of such a dermatitis, and we believe they are the first to be recorded in this country. In our first patient a mild stomatitis was also present. In neither of our patients was the cause recognized at the time of the first attack, and no doubt in many cases a mild involvement is unrecognized. We desire to stress the point that such cases represent examples of contact dermatitis rather than of irritation of the skin and the mucosa resulting from the absorption of mercury from the amalgam fillings and to review briefly the literature on the controversial subject of chronic mercurial poisoning resulting from amalgam fillings.”

“The guinea-pigs inoculated with 1 c.cm. of the mixtures after 24 hours all died ; the first of merthiolate poisoning and the remainder either of or with tuberculosis.”

“In our tissue culture experiements phenol showed a smaller toxicity index than merthiolate.”

“Recent investigations have demonstrated the fact that metals in the mouth may set up electro-galvanic discharges.  These discharges take place between dissimilar metals, and, according to Solomon, Reinhard and Goodale, on some few occasions between alloys of the same type. THEORY: It is generally well known that electrical energy is produced when dissimilar metals are immersed in an electrolyte. The metals are found to be arranged in the electromotive force series from positive (highest potential) to negative as follows: (positive end) aluminum, zinc, chromium, iron, nickel, tin, copper, mercury, silver, palladium, platinum, gold (negative end). Electrogalvanic activity parallels chemical activity.”

“The purpose of this report is to present data on Merthiolate observed in laboratory studies…”