Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum.

Author: Vera-Lastra O, Medina G, Cruz-Dominguez MD, Jara LJ, Shoenfeld Y.

Source: Expert Review of Clinical Immunology.

Year: 2013

Comment:

Abstract / Excerpt:

An adjuvant is a substance that enhances the antigen-specific immune response, induces the release of inflammatory cytokines, and interacts with Toll-like receptors and the NALP3 inflammasome. The immunological consequence of these actions is to stimulate the innate and adaptive immune response. The activation of the immune system by adjuvants, a desirable effect, could trigger manifestations of autoimmunity or autoimmune disease. Recently, a new syndrome was introduced, autoimmune/inflammatory syndrome induced by adjuvants (ASIA), that includes postvaccine phenomena, macrophagic myofasciitis, Gulf War syndrome and siliconosis.

Citation: Vera-Lastra O, Medina G, Cruz-Dominguez MD, Jara LJ, Shoenfeld Y. Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld’s syndrome): clinical and immunological spectrum. Expert Review of Clinical Immunology. 2013; 9(4):361-73.