Cytotoxicity of amalgams.

Author: Kaga M, Seale NS, Hanawa T, Ferracane JL, Okabe T.

Source: J Dent Res.

Year: 1988

Comment:

This study examines the impact of different compositions of amalgam fillings on toxicity, including the addition of zinc and selenium.

Abstract / Excerpt:

“The purpose of this study was to compare the relative cytotoxicity of amalgams and to determine whether their toxicity depends upon composition and aging time, by means of a rapid and sensitive in vitro cell culture test. Zinc-containing amalgams showed higher cytotoxicity than did any other amalgams. High-copper amalgams had the same cytotoxicity as did the low-copper amalgam. The addition of selenium did not reduce the cytotoxicity of amalgam. Moreover, excessive additions of selenium increased the cytotoxicity of amalgam compared with that of a similar selenium-free material. The cytotoxicity of amalgam was decreased with aging time, possibly due to the combined effects of surface oxidation and further amalgamation.”

Citation:

Kaga M, Seale NS, Hanawa T, Ferracane JL, Okabe T. Cytotoxicity of amalgams. J Dent Res. 1988; 67(9):1221-4.