Genotoxic effect of an environmental pollutant, sodium fluoride, in mammalian in vivo test system

Author: Pati PC, Bhunya SP.

Source: Caryologia.

Year: 1987

Comment:

Abstract / Excerpt:

Genotoxicity of Sodium fluoride was evaluated in mice in vivo with the help of different cytogenetic assays. The frequency of chromosome aberration was dose—and time—dependent but not exactly route-dependant. Fractionated dosing induced less aberration. Incidence of micronucleus and sperm abnormality increased with dose. Relative sensitivity of the three assays has been found to be: Sperm abnormality > Chromosome aberration > Micronucleus. The present results have revealed the mutagenic property of NaF.

Citation: Pati PC, Bhunya SP. Genotoxic effect of an environmental pollutant, sodium fluoride, in mammalian in vivo test system. Caryologia. 1987; 40(1-2):79-87.