HLA-association in patients with intolerance to mercury and other metals in dental materials.

Author:

Source: Dis Markers.

Year: 2000

Comment:

While this study examined individuals intolerant to heavy metals in their dental amalgam fillings for HLA antigens, it concluded more studies are needed: "These results provide an indication about the possible role of HLA molecules for intolerance to heavy metals. However the significance of the HLA associations has to be confirmed on larger groups of patients."

Abstract / Excerpt:

“A group of selected 25 patients with serious intolerance to heavy metals used for dental restoration were examined for HLA antigens. A significant increase for HLA — B37, B47 and DR4 was found. The value of the relative risk is not significant after correction for the number of antigens tested and therefore further studies of more patients are needed.”

Citation:

Prochazkova J, Bartova J, Ivašková E, Kupkova L, Šterzl I, Stejskal VDM. HLA-association in patients with intolerance to mercury and other metals in dental materials. Dis Markers. 2000; 16(3-4):135-8.