In vitro evaluation of inorganic mercury and methylmercury effects on the intestinal epithelium permeability.

Author: Vázquez M, Vélez D, Devesa V.

Source: Food Chem Toxicol.

Year: 2014

Comment:

The researchers conclude, "In vivo studies are needed to confirm the in vitro findings and allow us to firmly conclude that the mercurial forms are able to disrupt the intestinal barrier at the concentrations commonly found in foods."

Abstract / Excerpt:

“The mercurial forms [inorganic divalent mercury, Hg(II) and methylmercury, CH₃Hg] produce neurological and immune effects as well as hematological and renal alterations. The main route of exposure is through the diet. Consequently, the gastrointestinal mucosa is exposed to these mercurial forms, though the potential toxic effects upon the mucosa are not clear. The present study evaluates the toxicity of Hg(II) and CH₃Hg (0.1–2 mg/L) in an intestinal epithelium model using the differentiated and undifferentiated human Caco-2 cell line.”

Citation:

Vázquez M, Vélez D, Devesa V. In vitro evaluation of inorganic mercury and methylmercury effects on the intestinal epithelium permeability. Food Chem Toxicol. 2014;74:349-59.