Mercury-EDTA Complex Specifically Blocks Brain Beta-Tubulin-GTP Interactions: Similarity to Observations in Alzheimer's Disease

Author: Pendergrass JC, Haley BE

Source: Status Quo and Perspective of Amalgam and Other Dental Materials. International Symposium Proceedings.

Year: 1995

Comment:

The researchers conclude, "Using the technique of photoaffinity labeling, our laboratory has shown that beta-tubulin is the major photolabeled protein in control human brain samples. In contrast, in 80 percent of Alzheimer's diseased brain samples the photoinsertion into beta-tubulin is significantly decreased."

Abstract / Excerpt:

“The regulation of most biochemical pathways and transport systems involves protein-nucleotide interactions. In general, nucleotides regulate the properties of proteins by contributing free energy through tvm pathways. The first is by binding causing conformation changes that affect activities.”

Citation:

Pendergrass JC, Haley BE. Mercury-EDTA Complex Specifically Blocks Brain Beta-Tubulin-GTP Interactions: Similarity to Observations in Alzheimer's Disease. Status Quo and Perspective of Amalgam and Other Dental Materials. International Symposium Proceedings. 1995; 98-105.