Risk of subsequent attention‐deficit/hyperactivity disorder among children and adolescents with amalgam restorations: A nationwide longitudinal study.

Author: Lin PY, Wang J, Chiang YC, Lai CY, Chang HJ, Chi LY.

Source: Community Dentistry and Oral Epidemiology.

Year: 2018

Comment:

Abstract / Excerpt:

In conclusion, we found that younger people with six or more amalgam restorations exhibited a 20%-fold elevated risk of future ADHD in the univariate Cox model, relative to those who received composite resin or glass ionomer restorations. However, that the association disappeared after adjustment for age may indicate that those with six or more amalgam restorations were slightly older and may have had a longer exposure period in which to develop/be diag-nosed with ADHD. This demonstrates the difficulty in interpreting findings from large observational studies such as this where con-founding may be subtle but important. Thus, the current findings revealed that the receipt of amalgam restorations in young patients was not associated with a higher risk of future diagnosis of ADHD.

Citation: Lin PY, Wang J, Chiang YC, Lai CY, Chang HJ, Chi LY. Risk of subsequent attention‐deficit/hyperactivity disorder among children and adolescents with amalgam restorations: A nationwide longitudinal study. Community Dentistry and Oral Epidemiology. 2018; 46(1):47-53.