Author: Lechner J, Von Baehr V.
Source: Journal of Dental and Oral Health
Year: 2017
Comment:
Abstract / Excerpt:
Background and Introduction: The transition from acute local inflammation following
wisdom tooth surgery to a chronic stage of “Silent Inflammation” could be a neglected
cause of unexplained medical conditions.
Case Report: Here we will refer to an unusual case of recurrent syncope in a 19-yearold
woman whose 12 months of treatment in various clinics, and wide range of prescribed
medications, failed to bring about any improvement in her condition.
Material and Methods: As previous analyses of the cytokine profile in fatty-degenerative
osteonecrosis of the jawbone (Fdoj) show local overexpression of the chemokine Rantes/
Ccl-5 (R/C), this case further supports the suspicion of a chronic inflammatory process.
Results: Stepwise surgical removal of Fdoj areas containing insufficiently healed,
osteonecrotic medullary cavities resulted in the permanent cessation of syncope episodes
by removing local sources of r/c.
Discussion: Following a study of the relevant literature on the effects of chemokines in
the central nervous system (Cns), We focus here on the interconnected disease pathways
of peripheral R/C overexpression and disorders of the Cns. A change in peripheral immune
regulation in the jaw provokes a chronically aggressive immune response in the Cns. If both
systems fail to resume normal functioning, this maladaptation results in a dire neurological
response pattern in this young patient.
Conclusion: The incomplete wound healing and associated “Silent Inflammation” in
the jawbone may contribute via peripheral, local R/c overexpression to various symptoms
in the Cns which are typical of chemokine’s. From a systemic perspective, we recommend
that more attention be paid to this cytokine cross-talk in medicine and dentistry.
Citation: Lechner J, Von Baehr V. Silent Inflammation in the Jaw and Neurological Dysregulation-Case Study Linking Rantes/Ccl5 Overexpression in Jawbone with Chemokine Receptors in the Central Nervous System. Of. 2017;7:2.