Studies on H1N1 vaccine-induced monoamines alternations and oxidative stress on brain of adult mice.

Author: Abdel-Rahman M, Mohamed AF, Essam N, Moneim AEA.

Source: Journal of Applied Pharmaceutical Science.

Year: 2013

Comment:

This research is related to thimerosal.

Abstract / Excerpt:

“Results obtain on the present study showed that thiomerosal, H1N1 antigen and H1N1 vaccine were caused significant decrease in norepinephrine (NE) and dopamine (DA) contents of hypothalamus, striatum and cerebral cortex. The alternation in NE and DA was associated with significant increase in oxidative markers namely lipid peroxidation and nitric oxide, oxidation induction was extent to cause significant decrease in glutathione level. In conclusion, the present study demonstrated that H1N1 vaccine as a whole and/or its ingredient caused oxidative stress and monoamines alternations in brain of mice. The present observation could be due to the presence of thiomerosal.”

Citation:

Abdel-Rahman M, Mohamed AF, Essam N, Moneim AEA. Studies on H1N1 vaccine-induced monoamines alternations and oxidative stress on brain of adult mice.  Journal of Applied Pharmaceutical Science.  2013; 3(4): 48-53.