Teratogenicities of ophthalmic drugs. II. Teratogenicities and tissue accumulation of thimerosal.

Author: Gasset AR, Itoi M, Ishii Y, Ramer RM.

Source: Arch Ophthalmol.

Year: 1975

Comment:

Abstract / Excerpt:

“Under the conditions of this study, systemically or topically applied thimerosal was found to have no teratogenic effect even when given in concentrations approaching the 50% lethal dose of these compounds. A comparison of topical and subcutaneous administration of thimerosal to rabbits shows that a substantial concentration of mercury was present in blood and tissues of the treated animals and their offspring. Thimerosal was found to cross the blood-brain and placenta barriers.”

Citation:

Gasset AR, Itoi M, Ishii Y, Ramer RM. Teratogenicities of ophthalmic drugs. II. Teratogenicities and tissue accumulation of thimerosal. Arch Ophthalmol. 1975; 93(1): 52-55.