The influence of sodium fluoride and sodium hexafluorosilicate on human leukemic cell lines.

Author: Machalinski B, Baskiewicz-Masiuk M, Sadowska B, Machalinska A, Marchlewicz M, Wiszniewska B, Stecewicz I.

Source: Fluoride

Year: 2003

Comment:

Abstract / Excerpt:

Although potential toxic effects of sodium fluoride on early pro-genitor and stem cells have been reported previously, surprisingly few inves-tigations have examined the effects of fluoride on human leukemic cells. To address this need, four different human leukemic cell lines (HL-60, HEL, TF-1, and K562) were exposed to increasing levels (0, 0.24, and 1.19 mM F) of two forms of fluoride: sodium fluoride (NaF) and sodium hexafluorosilicate (Na2SiF6). Because of its widespread use in water fluoridation, Na2SiF6 was investigated in addition to NaF.  The early response effect of Na2SiF6 was greater, and in several cases significantly greater, than NaF on clonogenic growth and the induction of apoptosis in all four cell lines.  These findings show that human leukemic cells can be influenced and damaged by fluorine compounds.

Citation: Machalinski B, Baskiewicz-Masiuk M, Sadowska B, Machalinska A, Marchlewicz M, Wiszniewska B, Stecewicz I. The influence of sodium fluoride and sodium hexafluorosilicate on human leukemic cell lines. Fluoride. 2003; 36(4):231-40.