Within-subject associations between inflammation and features of depression: Using the flu vaccine as a mild inflammatory stimulus.

Author: Kuhlman KR, Robles TF, Dooley LN, Boyle CC, Haydon MD, Bower JE.

Source: Brain, Behavior, and Immunity.

Year: 2018

Comment:

Abstract / Excerpt:

Conclusions: Minor increases in inflammation were associated with corresponding increases in features of depression, and these associations occurred in the absence of any physical symptoms. The influenza vaccine could be used to probe causal relationships with a high degree of ecological validity, even in high-risk and vulnerable populations, to better understand the role of inflammation in the pathogenesis of depression.

Citation: Kuhlman KR, Robles TF, Dooley LN, Boyle CC, Haydon MD, Bower JE. Within-subject associations between inflammation and features of depression: Using the flu vaccine as a mild inflammatory stimulus. Brain, Behavior, and Immunity. 2018; 69:540-7.