“Merthiolate should never be given in amounts exceeding 0.15 gram per 100 lbs. of body weight; nor more frequently than once in 10 days. This drug should not be used if there is evidence of active hemorrhagic nephritis.”
“The effect of an antiseptic on body tissue is relatively of greater importance than the ability of that antiseptic to destroy living microorganisms.”
“The toxic effect of germicides when tested on human or guinea pig blood as a tissue appears to be directed against the humoral in contrast to the cellular elements.”
MERCURY has ranked prominently among the causes of poisoning for several hundred years. It was known to the Egyptians in 1600 BC The knowledge of mercury accompanied the gradual spread of Egyptian culture to Greece, and from Greece the information passed to Rome, and thence over the Roman Empire. The Egyp-tians, Greeks, and Romans considered mercury too toxic for medicinal use. Mercury was known in India about 500 BC where its medicinal value was recognized during the 1st century AD, and mercury stomatitis was described during this time.
“Reported instances of dermatitis or stomatitis from the mercury of amalgam fillings are rare, but undoubtedly such cases occur more frequently than a review of the literature would indicate. We have recently observed 2 examples of such a dermatitis, and we believe they are the first to be recorded in this country. In our first patient a mild stomatitis was also present. In neither of our patients was the cause recognized at the time of the first attack, and no doubt in many cases a mild involvement is unrecognized. We desire to stress the point that such cases represent examples of contact dermatitis rather than of irritation of the skin and the mucosa resulting from the absorption of mercury from the amalgam fillings and to review briefly the literature on the controversial subject of chronic mercurial poisoning resulting from amalgam fillings.”
“The guinea-pigs inoculated with 1 c.cm. of the mixtures after 24 hours all died ; the first of merthiolate poisoning and the remainder either of or with tuberculosis.”
“In our tissue culture experiements phenol showed a smaller toxicity index than merthiolate.”
“Recent investigations have demonstrated the fact that metals in the mouth may set up electro-galvanic discharges. These discharges take place between dissimilar metals, and, according to Solomon, Reinhard and Goodale, on some few occasions between alloys of the same type. THEORY: It is generally well known that electrical energy is produced when dissimilar metals are immersed in an electrolyte. The metals are found to be arranged in the electromotive force series from positive (highest potential) to negative as follows: (positive end) aluminum, zinc, chromium, iron, nickel, tin, copper, mercury, silver, palladium, platinum, gold (negative end). Electrogalvanic activity parallels chemical activity.”
“The purpose of this report is to present data on Merthiolate observed in laboratory studies…”
“Dangerous anaphylatic reactions may follow the first or subsequent daily intravenous injections of anti-meningococcic serum.”